PsychonautWiki marks this substance entry as unapproved. Its information may be incomplete or awaiting review.
MDAI
Overview
A selective serotonin and norepinephrine releasing agent which is rarely used without a stimulant to obtain desirable effects. The drug was previously believed to not be neuruotoxic, MDAI has been implicated in several lethal and non-lethal intoxications, and as such may pose more of a risk to one's health than previously believed.
Sources & licencesPsychonautWiki·TripSit·PubChem chemical identifiers
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The SMILES and basic chemical identifiers are resolved from the linked PubChem record. Fracton renders the molecule locally as inline SVG.
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Show SMILES
C1C(CC2=CC3=C(C=C21)OCO3)NDose
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Safety
- Addiction potential
- somewhat habit-forming with a low potential for abuse
- Full tolerance
- develops with prolonged and repeated use
- Half tolerance
- 3 - 7 days
- Zero tolerance
- 1 - 2 weeks
- Cross-tolerance with
- entactogens
EffectsPsychonautWikiEffectIndex
Visual
3Colour enhancement
Colour enhancement is a perceived intensification of the brightness and vividness of colours in the external environment. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Tracers
Tracers are the experience of visual trails of varying lengths and opacity being left behind moving objects. They are most commonly induced under the influence of mild dosages of psychedelic compounds.
Open full explainer on EffectIndex↗Visual acuity enhancement
Visual acuity enhancement is a heightening of the clearness and clarity of vision. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Cognitive
14Anxiety
Anxiety is medically recognized as the experience of negative feelings of apprehension, worry, and general unease. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants
Open full explainer on EffectIndex↗Anxiety suppression
Anxiety suppression (also known as anxiolysis or minimal sedation) is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants, such as benzodiazepines, alcohol, GHB, and gabapentinoids.
Open full explainer on EffectIndex↗Cognitive euphoria
Cognitive euphoria (semantically the opposite of cognitive dysphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of well-being, elation, happiness, excitement, and joy. It is most commonly induced under the influence of moderate dosages of opioids, entactogens, stimulants, and GABAergic depressants. However, it can also occur to a lesser extent under the influence of hallucinogenic compounds such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Cognitive fatigue
Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.
Open full explainer on EffectIndex↗Depression
Depression medically encompasses a large variety of different mood disorders whose common features are a sad, empty, or irritable mood co-occurring with bodily and cognitive changes that significantly disrupt an individual's ability to function. Within the context of psychoactive substance usage, depressivity is often accompanied by other coinciding effects such as anxiety, irritability and dysphoria.
Open full explainer on EffectIndex↗Empathy, affection, and sociability enhancement
Empathy, affection, and sociability enhancement is the experience of a mind state that is dominated by intense feelings of compassion, talkativeness, and happiness. It is most commonly induced under the influence of moderate dosages of entactogenic compounds, such as MDMA, 4-FA, and 2C-B.
Open full explainer on EffectIndex↗Immersion enhancement
Immersion enhancement is an effect that results in a pronounced increase in one's tendency to become fully captivated and engrossed by external stimuli, such as film, TV shows, video games, and various other forms of media. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Increased music appreciation
Increased music appreciation is a general sense of an increased enjoyment of music. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids
Open full explainer on EffectIndex↗Irritability
Irritability is medically recognized as the pervasive and sustained emotional state of being easily annoyed and provoked to anger. It is most commonly induced during the after effects of heavy dosages of stimulant compounds, such as cocaine, methamphetamine, and methylphenidate.
Open full explainer on EffectIndex↗Mindfulness
Mindfulness is the self-regulation of attention so that focus is directed towards immediate experience alongside of an orientation characterized by acceptance and a lack of judgement. It can occur under the influence of substances but is also practiced during meditation.
Open full explainer on EffectIndex↗Motivation suppression
Motivation suppression (also known as avolition or amotivation) is a decreased desire to initiate or persist in goal-directed behavior. It is most commonly induced under the influence of an acute dosage of an antipsychotic compound, such as quetiapine, haloperidol, and risperidone. However, it is worth noting that chronic treatment with any dose of antipsychotic medication does not cause this effect.
Open full explainer on EffectIndex↗Thought deceleration
Thought deceleration is the process of thought being slowed down significantly in comparison to that of normal sobriety. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, antipsychotics, and opioids.
Open full explainer on EffectIndex↗Time distortion
Time distortion is an effect that makes the passage of time feel wildly altered and difficult to keep track of. is most commonly induced under the influence of strong dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Wakefulness
Wakefulness is an increased ability to stay conscious without feeling sleepy combined with a decreased need to sleep. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as stimulants, nootropics, and psychedelics.
Open full explainer on EffectIndex↗Auditory
1Auditory enhancement
An auditory enhancement is the experience of an increase or improvement of the acuteness and clarity of sound. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Tactile
2Spontaneous tactile sensations
Spontaneous tactile sensations are the experience of sensations across the body occurring without any obvious or immediate physical trigger. This results in feelings of seemingly random yet distinct tingling sensations that occur across the skin and within the body. Depending on the psychoactive substance consumed, these vary greatly in their styles of sensation.
Open full explainer on EffectIndex↗Tactile enhancement
Tactile enhancement is an overall increase in both the intensity of a person's sense of touch and their awareness of the physical sensations across their body. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Emotional & social
1Physical euphoria
Physical euphoria can be described as feelings of pleasure and comfort within and across one's body. This euphoria typically feels somewhat comparable to the endorphin rushes felt during states of excitement or love, the coziness of a comfortable bed, and the rush of an orgasm. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as opioids, stimulants, psychedelics, and GABAergics.
Open full explainer on EffectIndex↗Physical & bodily
7Dehydration
Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.
Open full explainer on EffectIndex↗Difficulty urinating
Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.
Open full explainer on EffectIndex↗Increased perspiration
Increased perspiration, or hyperhidrosis, can be described as a condition characterized by increased sweat which is in excess of that required for the regulation of body temperature. It is most commonly induced under the influence of stimulants, psychedelics, and benzodiapine or alcohol withdrawals.
Open full explainer on EffectIndex↗Sedation
Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.
Open full explainer on EffectIndex↗Temperature regulation suppression
Temperature regulation suppression can be defined as an inability to maintain a normal temperature. It is most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-B, and AMT.
Open full explainer on EffectIndex↗Temporary erectile dysfunction
Temporary erectile dysfunction can be described as a difficulty in achieving and maintaining an adequately erect penis for the purpose of sexual intercourse. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants and certain psychedelics. However, it can also occur under the influence of opioids, dissociatives, GABAergics, and deliriants.
Open full explainer on EffectIndex↗Vibrating vision
Vibrating vision, also known as nystagmus, is the experience of constant, rapid involuntary eye movements in which the eyes shift from left to right in such quick succession that the person's vision begins to vibrate and blur. It is most commonly induced under the influence of heavy dosages of stimulant compounds, such as MDMA, amphetamine, and 4-FA.
Open full explainer on EffectIndex↗No effects match that search.
Timing
Only onset and total duration are available for this route, so an intensity curve would be misleading.
Testing
Reagent test reference
The colour bars follow the written reaction sequence from the source. Rows without a bar are explicit results recorded by the source, not missing data. Reagents cannot establish identity, purity, or potency.
Reported appearance: Orange or brown.
Reported reaction: Greenish dark brown, then brown.
Reported appearance: Very dark brown.
Reported reaction: Dark green, then dark brown.
Reported appearance: Dark brown.
Reported appearance: Orange.
No color change
No pink color change
Grey precipitates
No color change
No color change
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