Pupil dilation can be described as the enlargement of the size of a person's pupils under normal lighting conditions. This is most commonly induced under the influence of moderate dosages of a wide variety of serotonergic compounds, such as psychedelics, dissociatives, deliriants, entactogens, various stimulants, and some antidepressants.

Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.

Motivation suppression (also known as avolition or amotivation) is a decreased desire to initiate or persist in goal-directed behavior. It is most commonly induced under the influence of an acute dosage of an antipsychotic compound, such as quetiapine, haloperidol, and risperidone. However, it is worth noting that chronic treatment with any dose of antipsychotic medication does not cause this effect.

Personal bias suppression is a decrease in the cultural biases that a person filters their perception through. It is most commonly induced under the influence of hallucinogenic substances.

Personality regression is a mental state in which one suddenly adopts an identical or similar personality, thought structure, mannerisms and behaviours to that of their past self from a younger age. It is a relatively rare effect that is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, most notably Ayahuasca, LSD and Ibogaine in particular as well as certain dissociatives.