An autonomous entity is the experience of perceived contact with beings that appear to be sentient in their behaviour. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds.

Brightness alteration is a distortion or change in the intensity of perceived brightness comprising a person's vision. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.

Double vision is the experience of seeing duplicated vision, similar to when one crosses their eyes. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.

Drifting is the experience of the texture, shape, and general structure of objects and scenery appearing progressively warped, melted, and morphed across themselves. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.

An external hallucination is the perception of a visual hallucination that displays itself seamlessly into the external environment as if it were physically present. They are most commonly induced under the influence of heavy dosages of deliriant compounds.

An internal hallucination is the perception of a visual hallucination that exclusively occurs within an imagined environment that can typically only be viewed with closed eyes, similar to those found within dreams. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

Object activation is the experience of looking at an object and perceiving it to move, become alive, or become fully animated and autonomous of its own accord. It is most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.

An object alteration is the experience of perceiving objects and scenes to be progressively warping, moving, stretching, animating, and shifting in their 3-dimensional form. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH and datura.

Peripheral information misinterpretation is a fleeting experience of an object or detail within one's peripheral vision being interpreted and displayed incorrectly. It is most commonly induced under the influence of moderate dosages of deliriant compounds, such as DPH, datura, and benzydamine.

A perspective hallucination is an alteration of the perspective through which a given internal or external hallucination is seen through. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

Pupil constriction (also called pinpoint pupils or miosis) can be described as the reduction of the size of a person's pupils under normal lighting conditions. It is most commonly induced under the influence of moderate dosages of opioid compounds, such as heroin, kratom, tramadol, and fentanyl.

Pupil dilation can be described as the enlargement of the size of a person's pupils under normal lighting conditions. This is most commonly induced under the influence of moderate dosages of a wide variety of serotonergic compounds, such as psychedelics, dissociatives, deliriants, entactogens, various stimulants, and some antidepressants.

Settings, sceneries, and landscapes are the perceived environments in which the plot of an internal or external hallucination occurs. This effect is capable of manifesting in a seemingly infinite variety of potential places and settings. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

Shadow people are the experience of perceiving patches of shadow in one's peripheral or direct line of sight to appear and behave as living, autonomous beings. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.

Transformations are the experience of a perceived visual metamorphosis that specific parts of one's external environment undergo as they shapeshift into other objects. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.

Unspeakable horrors describe the experience of prolonged exposure to indescribable scenarios and hallucinatory content of a scary and disturbing nature, which are often directly influenced by a person's fears. They are most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and 2C-P.

Acuity suppression is the degradation of the sharpness and clarity of one's vision, resulting in vision becoming partially to completely blurred and indistinct. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.

Visual agnosia is a partial to complete inability to mentally process visual information, regardless of its clarity. It is most commonly induced under the influence of heavy dosages of dissociative or antipsychotic compounds, such as ketamine, quetiapine, PCP, and DXM.

Visual haze distorts the surrounding environment to make it appear as if the air is shrouded in an imaginary cloud of smoke, fog, or haze. It is most commonly induced under the influence of mild dosages of hallucinogenic compounds, such as psychedelics, deliriants, and cannabinoids.

An abnormal heartbeat is any of a group of conditions in which the electrical activity of the heart is irregular. During this state, the heartbeat may be too fast (over 100 beats per minute) or too slow (less than 60 beats per minute) and may be regular or irregular. An abnormal heartbeat is most commonly induced under the influence of moderate dosages of stimulant and depressant compounds, such as cocaine, methamphetamine, and GABAergics.

Appetite suppression can be described as the experience of a distinct decrease in a person's sense of hunger and appetite in a manner which can result in both a lesser desire to eat food and a decreased enjoyment of its taste. It is most commonly induced under the influence of moderate dosages of stimulant compounds, such as amphetamine, methylphenidate, nicotine, MDMA, and cocaine.

Cough suppression can be described as a decreased desire and need to cough. It is most commonly induced under the influence of moderate dosages of antitussive compounds such as, codeine, pholcodine, dextromethorphan, noscapine, and butamirate.

Decreased blood pressure can be described as a condition in which the pressure in the systemic arteries is decreased to abnormal levels. It is most commonly induced under the influence of moderate dosages of GABAergic depressant compounds, such as benzodiazepines and barbiturates.

Decreased libido can be described as a distinct decrease in feelings of sexual desire, the anticipation of sexual activity, and the likelihood that a person will view the context of a given situation as sexual in nature. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as, opioids, antipsychotics and SSRI's, and dissociatives.

Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.

Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.

Dizziness can be described as the perception of a spinning or swaying motion which typically causes a difficulty in standing or walking. It is most commonly induced under the influence of heavy dosages of GABAergic depressant compounds, such as benzodiazepines, alcohol, and GHB.

Dry mouth can be described as having a dry-feeling mouth often accompanied by a difficulty swallowing. It is usually a direct result of dehydration but can be felt to occur regardless of the actual dryness of a person's mouth. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, opioids, antispychotics, deliriants, SSRI's, and cannabinoids.

Frequent urination, or urinary frequency, can be defined as the need to urinate more often than usual. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, dissociatives, and deliriants.

Increased bodily temperature or pyrexia can be described as having a body temperature which is above normal baseline. It is most commonly induced under the influence of heavy dosages of stimulant compounds which affect serotonin and 5-HT receptors, dopamine and D receptors and norepinephrine.

Increased heart rate or tachycardia is described as a heart rate that is faster than the normal heart rate at rest. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.

Increased perspiration, or hyperhidrosis, can be described as a condition characterized by increased sweat which is in excess of that required for the regulation of body temperature. It is most commonly induced under the influence of stimulants, psychedelics, and benzodiapine or alcohol withdrawals.

Motor control loss can be described as feeling as if there has been a distinct decrease in a person's ability to control their physical body with precision, balance, coordination, and dexterity. Motor control loss is often accompanied by other coinciding effects such as sedation and disinhibition. It is most commonly induced under the influence of moderate dosages of GABAergic depressant compounds, such as, alcohol, benzodiazepines, GHB, and phenibut.

A muscle cramp can be described as an involuntary temporary contraction or over shortening of muscles which may cause severe aches and pains. They are most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-E, DOC, and AMT. However, they can also occur under the influence of certain GABAergic depressants such as GHB and phenibut.

Nausea can be described as a sensation of unease and discomfort in the upper stomach combined with an involuntary urge to vomit. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, deliriants, dissociatives, and stimulants.

Nausea suppression can be described as a reduction in vomiting, stomach cramps, and general feelings of nausea. It is most commonly induced under the influence of 5-HT3 receptor antagonists, cannabinoids, benzodiazepines, antihistamines, and others.

Perception of bodily heaviness can be described as feeling as if one's body has significantly increased in its weight. This can result in feelings of slowness and sluggishness due to the body seeming difficult, uncomfortable, or impossible to move. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, opioids, and antipsychotics.

Physical fatigue can be described as a general feeling of bodily exhaustion. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants, and during the offset of many stimulants.

Restless legs (also known as restless legs syndrome or RLS) is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. Restless legs syndrome is most commonly induced during the withdrawal symptoms of many depressants, such as opioids or benzodiazepines, and during the offset of many stimulants, such as methamphetamine, cocaine, and MDMA. However, it can also occur under the influence of deliriants such as DPH and datura.

Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.

Teeth grinding (also known as bruxism, jaw clenching, and gurning) can be described as a compulsive and often uncontrollable urge to grind one's teeth. It is most commonly induced under the influence of common dosages of stimulant compounds, such as methamphetamine, MDMA, methylphenidate, and cocaine. However, it can also occur under the influence of certain stimulating psychedelics such as 2C-E, DOC, and AMT.

Temperature regulation suppression can be defined as an inability to maintain a normal temperature. It is most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-B, and AMT.

Temporary erectile dysfunction can be described as a difficulty in achieving and maintaining an adequately erect penis for the purpose of sexual intercourse. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants and certain psychedelics. However, it can also occur under the influence of opioids, dissociatives, GABAergics, and deliriants.

Scenarios and plots are the situations, stories, and events that occur within both external and internal hallucinations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

An auditory enhancement is the experience of an increase or improvement of the acuteness and clarity of sound. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.

An auditory hallucination is the experience of hearing spontaneous and imaginary noises. They are most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.

Auditory suppression is the experience of sound becoming perceived as more distant, quiet, and muffled than they actually are. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.

Itchiness is the sensation that causes a person the desire or reflex to scratch at their skin. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, fentanyl, tramadol, and kratom.

Muscle twitching can be described as the sensation of small and localised tremblings of muscle groups. These vibrations are often powerful enough to be visibly seen through the skin. It is most commonly induced under the influence of moderate dosages of stimulating psychedelic compounds such as LSD, 2C-E, DOC, and AMT.

Skin flushing can be described as the experience of a sudden reddening of the skin which is usually accompanied by feelings of rushing blood and warm skin. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom. However, it can also occur under the influence of alcohol, certain psychedelics such as 5-MeO-DMT, and stimulants, such as caffeine.

Spontaneous tactile sensations are the experience of sensations across the body occurring without any obvious or immediate physical trigger. This results in feelings of seemingly random yet distinct tingling sensations that occur across the skin and within the body. Depending on the psychoactive substance consumed, these vary greatly in their styles of sensation.

Tactile enhancement is an overall increase in both the intensity of a person's sense of touch and their awareness of the physical sensations across their body. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.

A tactile hallucination is the experience of perceiving a convincing physical sensation that is not actually occurring. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.

Tactile suppression is a decrease in one's ability to feel their sense of touch, which may result in a general numbness across the body. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.

A gustatory hallucination is any hallucination that involves one's sense of taste. A common example of this is a strong, unpleasant metallic taste in one's mouth. They are most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

An olfactory hallucination (also known as phantosmia) is the detection or perception of a convincing imaginary smell that is not actually present in the person's environment. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as deliriants and psychedelics.

Amnesia is a global impairment in the ability to acquire new memories regardless of sensory modality, and a loss of some memories, especially recent ones, from the period before amnesia began. It is most commonly induced under the influence of heavy dosages of GABAergic depressants, such as alcohol, benzodiazepines, GHB, and zolpidem.

Analysis suppression is a distinct decrease in a person's overall ability to process information and logically or creatively analyze concepts, ideas, and scenarios. It is most commonly induced under the influence of heavy dosages of antipsychotic compounds, and is associated with long term use of such drugs like quetiapine, haloperidol, and risperidone.

Anxiety is medically recognized as the experience of negative feelings of apprehension, worry, and general unease. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants

Cognitive dysphoria (semantically the opposite of euphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of dissatisfaction, and in some cases indifference to the world around them. It is most commonly induced under the influence of moderate dosages of deliriant compounds, such as DPH and datura. However, it can also occur during a stimulant's offset and during the withdrawal symptoms of almost any substance.

Cognitive euphoria (semantically the opposite of cognitive dysphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of well-being, elation, happiness, excitement, and joy. It is most commonly induced under the influence of moderate dosages of opioids, entactogens, stimulants, and GABAergic depressants. However, it can also occur to a lesser extent under the influence of hallucinogenic compounds such as psychedelics, dissociatives, and cannabinoids.

Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.

Confusion is an impairment of abstract thinking demonstrated by an inability to think with one’s customary clarity and coherence. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, synthetic cannabinoids, and deliriants.

Creativity suppression is a decrease in both a person's motivation and capabilities when performing tasks that involve producing artistic output or novel problem-solving. It is most commonly induced under the influence of moderate dosages of antipsychotics.

Delirium (also known as acute confusion) is medically recognized as a physiological disturbance of awareness that is accompanied by a change in baseline cognition which cannot be better explained by a preexisting or evolving neurocognitive disorder. The disturbance in awareness is manifested by a reduced ability to direct, focus, sustain, and shift attention and the accompanying cognitive change in at least one other area may include memory and learning (particularly recent memory), disorientation (particularly to time and place), alteration in language, or perceptual distortions or a perceptual-motor disturbance. It is most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.

A delusion is a false idea or belief that is held with strong conviction and subjective certainty and is inconsistent with an individual’s educational, cultural and social background. Delusions are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.

Depression medically encompasses a large variety of different mood disorders whose common features are a sad, empty, or irritable mood co-occurring with bodily and cognitive changes that significantly disrupt an individual's ability to function. Within the context of psychoactive substance usage, depressivity is often accompanied by other coinciding effects such as anxiety, irritability and dysphoria.

Derealization or derealisation (sometimes abbreviated as DR) is the experience of feeling detached from, and as if one is an outside observer of, one's surroundings (e.g., individuals or objects are experienced as unreal, dreamlike, foggy, lifeless, or visually distorted). It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.

Disinhibition is medically recognized as an orientation towards immediate gratification, leading to impulsive behavior driven by current thoughts, feelings, and external stimuli, without regard for past learning or consideration of future consequences. It is most commonly induced under the influence of moderate dosages of GABAergic depressants, such as alcohol, benzodiazepines, phenibut, and GHB.

Dream potentiation is an effect that increases the subjective intensity, vividness, and frequency of sleeping dream states. It is most commonly induced under the influence of moderate dosages of oneirogenic compounds, a class of hallucinogen that is used to specifically potentiate dreams when taken before sleep.

Emotion suppression (also known as flat affect, apathy, or emotional blunting) is medically recognized as a flattening or decrease in the intensity of one's current emotional state below normal levels. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.

Feelings of impending doom can be described as sudden sensations of overwhelming fear and urgency based upon the unfounded belief that a negative event is about to occur in the immediate future. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

Focus suppression is medically recognized as a decreased ability to selectively concentrate on an aspect of the environment while ignoring other things. It is most commonly induced under the influence of moderate or heavy dosages of antipsychotics, benzodiazepines, cannabinoids, and hallucinogens.

Glossolalia is an effect in which a person finds themselves involuntarily speaking and/or thinking in nonsensical speech which is structured in a manner that resembles an actual language. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.

Increased music appreciation is a general sense of an increased enjoyment of music. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids

Irritability is medically recognized as the pervasive and sustained emotional state of being easily annoyed and provoked to anger. It is most commonly induced during the after effects of heavy dosages of stimulant compounds, such as cocaine, methamphetamine, and methylphenidate.

Language suppression is the decreased ability to use and understand speech. It is most commonly induced under the influence of heavy dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.

Memory suppression is an inhibition of a person's ability to maintain a functional short and long-term memory. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.

Motivation suppression (also known as avolition or amotivation) is a decreased desire to initiate or persist in goal-directed behavior. It is most commonly induced under the influence of an acute dosage of an antipsychotic compound, such as quetiapine, haloperidol, and risperidone. However, it is worth noting that chronic treatment with any dose of antipsychotic medication does not cause this effect.

Paranoia is the suspiciousness or the belief that one is being harassed, persecuted, or unfairly treated. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants.

Psychosis is as an abnormal condition of the mind and a general psychiatric term for a mental state in which one experiences a "loss of contact with reality." It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as deliriants, psychedelics, dissociatives, and cannabinoids.

Sleepiness (also known as drowsiness) is medically recognized as a state of near-sleep, or a strong desire for sleep without feeling a decrease in one's physical energy levels. This state is independent of a circadian rhythm; so, unlike sedation, this effect does not necessarily decrease physical energy levels but instead decreases wakefulness. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as cannabinoids, GABAergic depressants, opioids, antipsychotics, some antihistamines, and certain psychedelics.

Thought deceleration is the process of thought being slowed down significantly in comparison to that of normal sobriety. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, antipsychotics, and opioids.

Thought disorganization is a state in which one's ability to analyze and categorize conceptual information using a systematic and logical thought process is considerably decreased. It is most commonly induced under the influence of heavy dosages of hallucinogenic and depressant compounds, such as dissociatives, psychedelics, cannabinoids, and GABAergics.

Time distortion is an effect that makes the passage of time feel wildly altered and difficult to keep track of. is most commonly induced under the influence of strong dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.

Wakefulness is an increased ability to stay conscious without feeling sleepy combined with a decreased need to sleep. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as stimulants, nootropics, and psychedelics.